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Gadodiamide is a contrast medium used for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. It provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS).
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MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging (MRI). [1] The most commonly used compounds for contrast enhancement are gadolinium-based contrast agents (GBCAs).
A variety of related chelate complexes have been developed, including gadodiamide. Reduced gadolinium compounds are known, especially in the solid state. Gadolinium(II) halides are obtained by heating Gd(III) halides in presence of metallic Gd in tantalum containers.
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The o-cresolpthalein methods are effective because it is a calcium binding dye. The gadolinium ion with a charge of +3 can be removed from gadodiamide using o-cresolphthalein. For these methods, glomerular filtration rate, or GFR, and time since gadodiamide was given should be recorded.
Gadofosveset (trade names Vasovist, Ablavar) is a gadolinium-based MRI contrast agent.It was used as the trisodium salt monohydrate form. [2] [3] It acts as a blood pool agent by binding to human serum albumin.
Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA).It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine).
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