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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
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It can explain why you don’t behave like or connect with the entire twelfth of the population that you share your zodiac sign with. After all, there are many layers to astrology! Image: Adobe.
Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
Executive producer Daley Pearson and "Bluey" voice actors Melanie Zanetti and Dave McCormack explain how "The Sign," the highly anticipated 28-minute special, was made.
A cardinal sign or cardinal symptom can also refer to the major sign or symptom of a disease. [12] Abnormal reflexes can indicate problems with the nervous system . Signs and symptoms are also applied to physiological states outside the context of disease, as for example when referring to the signs and symptoms of pregnancy , or the symptoms of ...