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Doxylamine is also a potent anticholinergic, meaning that it causes delirum at high doses—i.e., at much higher doses than recommended. [8] (Specifically it is an antagonist of the muscarinic acetylcholine receptors M 1 through M 5.) These sedative and deliriant effects have in some cases led to using the drug recreationally.
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours. [11] Common side effects include sleepiness, poor coordination, and upset stomach. [11] There is no clear risk of harm when used during pregnancy; however, use during breastfeeding is not recommended. [13]
[1] [2] It contains sulfadoxine (a sulfonamide) and pyrimethamine (an antiprotozoal). [3] For the treatment of malaria it is typically used along with other antimalarial medication such as artesunate. [3] In areas of Africa with moderate to high rates of malaria, three doses are recommended during the second and third trimester of pregnancy. [4]
Pregnancy category: AU: B3 [1] Routes of administration: By mouth: ATC code: G03FA17 ; ... which is used as a birth control pill to prevent pregnancy in women. ...
[1] [2] Medications, when administered to breastfeeding mothers, almost always are transferred to breast milk, albeit usually in small quantities. [3] The degree of impact on the nursing infant varies, with many medications posing minimal risk. Nonetheless, informed decision-making and professional guidance is needed.
Plasma concentration profiles of vutrisiran showed rapid absorption and elimination from systemic circulation. There was a dose-proportional increase in peak plasma concentrations Cmax and a slightly greater than dose-proportional increase in AUC∞ inf and AUC last after a single subcutaneous dose across the dose range studied in the phase I trial in healthy volunteers.
Estradiol valerate/dienogest (EV/DNG), sold under the brand names Lafamme, Natazia and Qlaira among others, is a combination product of estradiol valerate, an estrogen, and dienogest, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women. It is taken by mouth.