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Myristic acid (IUPAC name: tetradecanoic acid) is a common saturated fatty acid with the molecular formula CH 3 (CH 2) 12 COOH. Its salts and esters are commonly referred to as myristates or tetradecanoates. The name of the acyl group derived from myristic acid is myristoyl or tetradecanoyl.
Nonanoic acid CH 3 (CH 2) 7 COOH C9:0 Capric acid: Decanoic acid CH 3 (CH 2) 8 COOH C10:0 Undecylic acid: Undecanoic acid CH 3 (CH 2) 9 COOH C11:0 Lauric acid: Dodecanoic acid CH 3 (CH 2) 10 COOH C12:0 Tridecylic acid: Tridecanoic acid CH 3 (CH 2) 11 COOH C13:0 Myristic acid: Tetradecanoic acid CH 3 (CH 2) 12 COOH C14:0 Pentadecylic acid ...
Myristoylation is a lipidation modification where a myristoyl group, derived from myristic acid, is covalently attached by an amide bond to the alpha-amino group of an N-terminal glycine residue. [1] Myristic acid is a 14-carbon saturated fatty acid (14:0) with the systematic name of n-tetradecanoic acid.
Cervonic acid (or docosahexaenoic acid) has 22 carbons, is found in fish oil, is a 4,7,10,13,16,19-hexa unsaturated fatty acid. In the human body its generation depends on consumption of omega 3 essential fatty acids (e.g., ALA or EPA), but the conversion process is inefficient. [ 22 ]
Zelenirstat is a strong pan-N myristoyl transferase inhibitor, which prevents addition of myristic acid into penultimate glycine of protein with myristoylation signal, and initially has been introduced as anti-tumor drug. [1] [2] [3] It has completed phase I clinical trial and is going through escalation phase. [4]
In the case of poliovirus, it is known in vitro that interactions with receptors cause conformational rearrangements which release a virion protein called VP4.The N terminus of VP4 is myristylated and thus hydrophobic【myristic acid=CH 3 (CH 2) 12 COOH】. It is proposed that the conformational changes induced by receptor binding result in the ...
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Isopropyl myristate is a polar emollient and is used in cosmetic and topical pharmaceutical preparations where skin absorption is desired. It is also used as a treatment for head lice. [2]