Search results
Results from the WOW.Com Content Network
It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL. The reaction is characterized by the on-rate constant k on and the off-rate constant k off, which have units of M −1 s −1 and s −1, respectively. In equilibrium, the forward binding transition R + L → ...
Receptor–ligand binding kinetics also involves the on- and off-rates of binding. A main goal of receptor–ligand kinetics is to determine the concentrations of the various kinetic species (i.e., the states of the receptor and ligand) at all times, from a given set of initial concentrations and a given set of rate constants.
In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex. There are two main kinds of complex: compounds formed by the ...
The affinity between protein and ligand is given by the equilibrium dissociation constant K d or the inverse of the association constant 1/K a (or binding constant 1/K b) that relates the concentrations of the complexed and uncomplexed species in solution. The dissociation constant is defined as K d = [] [] []
The computer program was written on paper for reference. An instruction was represented by a configuration of on/off settings. After setting the configuration, an execute button was pressed. This process was then repeated. Computer programs also were automatically inputted via paper tape, punched cards or magnetic-tape. After the medium was ...
The term closure is often used as a synonym for anonymous function, though strictly, an anonymous function is a function literal without a name, while a closure is an instance of a function, a value, whose non-local variables have been bound either to values or to storage locations (depending on the language; see the lexical environment section below).
Power On (IEC 60417-5007) and Power Off (IEC 60417-5008) symbols are used to indicate positions of the rocker switch Power button marked with Standby symbol (IEC 60417-5009) turns the device on or off without fully disconnecting power supply. A power symbol is a symbol indicating that a control activates or deactivates a particular device.
Upon binding of an analyte to the ligand, the real-time kinetic rates (k on, k off) can be measured as changes in fluorescence intensity and the K d can be derived. This method can be used to investigate protein-protein interactions, as well as to investigate modulators of protein-protein interactions by assessing ternary complex formation.