Search results
Results from the WOW.Com Content Network
To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. [2] The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). [3]
Amyloid light chains deposition in shoulder joint causes enlarged shoulders, also known as "shoulder pad sign". [18] Amyloid light chain depositions can also cause bilateral symmetric polyarthritis. [18] The deposition of amyloid proteins in the bone marrow without causing plasma cell dyscrasias is called amyloidoma. It is commonly found in ...
Acute-phase serum amyloid A proteins (A-SAAs) are secreted during the acute phase of inflammation.These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade extracellular matrix.
Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. [ 5 ] [ 6 ] [ 7 ] SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. [ 8 ]
Both human samples and experimental models of Alzheimer's disease have been used to study the biochemical, cytological, and inflammatory characteristics of amyloid plaques. [4] Experimental studies have focused not only on delineating mechanisms by which plaques arise and proliferate, but also on discovering methods by which they can be ...
Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis. [1] The disease is caused when a person's antibody -producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains .
20219 Ensembl ENSG00000132703 ENSMUSG00000026542 UniProt P02743 P12246 RefSeq (mRNA) NM_001639 NM_011318 RefSeq (protein) NP_001630 NP_035448 Location (UCSC) Chr 1: 159.59 – 159.59 Mb Chr 1: 172.72 – 172.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein ...
APLP2 is part of a family of mammalian membrane proteins along with APLP1 and amyloid precursor protein (APP). [18] Since APP plays a key role in the molecular pathology of Alzheimer’s disease (AD), it has been hypothesized that APLP2 also plays a role in AD pathogenesis. [19]