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The splenic lymph nodes are found at the splenic hilum and in relation to the tail of the pancreas (pancreaticolienal lymph nodes). [1] [2] Their afferents are derived from the stomach, spleen, and pancreas. The splenic lymph nodes empty into the suprapancreatic, infrapancreatic and omental lymph nodes, which then drain to the coeliac nodes and ...
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
The gonads may pick up some tissue from the spleen, and as they descend through the abdomen during development, they can produce either a continuous or a broken line of deposited splenic tissue. [12] Splenosis is a condition where foci of splenic tissue undergo autotransplantation, most often following physical trauma or splenectomy.
The hilum is an indent on the concave surface of the lymph node where lymphatic vessels leave and blood vessels enter and leave. [5] Lymph enters the convex side of a lymph node through multiple afferent lymphatic vessels, and from there, it flows into a series of sinuses.
The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes at the hilum, either to veins or greater nodes. It carries filtered lymph out of the node. Efferent lymphatic vessels are also found in association with the thymus and spleen. This is in contrast to afferent ...
Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.. Numerous factors appear to be involved in the development of EMZL. In a small number of cases where there is a family history of a blood cancer particularly leukemia, or a number of autoimmune diseases such as Sjögren syndrome and lupus erythematosus, there is seen to be an increased frequency.
Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts , and they invade the mantle zone of splenic follicles and erode the marginal zone ...
The fibroelastic coat of the spleen invests the organ, and at the hilum is reflected inward upon the vessels in the form of sheaths. From these sheaths, as well as from the inner surface of the fibroelastic coat, numerous small fibrous bands, the trabeculae of the spleen (or splenic trabeculae), emerge from all directions; these uniting, constitute the frame-work of the spleen.