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PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model. [5] However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models
Simple mediation model. The independent variable causes the mediator variable; the mediator variable causes the dependent variable. In statistics, a mediation model seeks to identify and explain the mechanism or process that underlies an observed relationship between an independent variable and a dependent variable via the inclusion of a third hypothetical variable, known as a mediator ...
Direct repeats are a type of genetic sequence that consists of two or more repeats of a specific sequence. [1] In other words, the direct repeats are nucleotide sequences present in multiple copies in the genome. Generally, a direct repeat occurs when a sequence is repeated with the same pattern downstream. [1]
The direct limit of the direct system , is denoted by and is defined as follows. Its underlying set is the disjoint union of the A i {\displaystyle A_{i}} 's modulo a certain equivalence relation ∼ {\displaystyle \sim \,} :
In statistics, path analysis is used to describe the directed dependencies among a set of variables. This includes models equivalent to any form of multiple regression analysis, factor analysis, canonical correlation analysis, discriminant analysis, as well as more general families of models in the multivariate analysis of variance and covariance analyses (MANOVA, ANOVA, ANCOVA).
In linear algebra, a linear relation, or simply relation, between elements of a vector space or a module is a linear equation that has these elements as a solution.. More precisely, if , …, are elements of a (left) module M over a ring R (the case of a vector space over a field is a special case), a relation between , …, is a sequence (, …,) of elements of R such that
Direct reciprocity was proposed by Robert Trivers as a mechanism for the evolution of cooperation. [1] If there are repeated encounters between the same two players in an evolutionary game in which each of them can choose either to "cooperate" or "defect", then a strategy of mutual cooperation may be favoured even if it pays each player, in the short term, to defect when the other cooperates.
The structures they form also form parts of complex protein signaling pathways. [7] In one respect, tight junctions play a generic role in cell signaling in that they may form a tight zip around cells, forming a barrier to stop even small, unwanted signalling molecules from getting between cells. [ 8 ]