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The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia was the last diagnosis to benefit from the link made between ACEs and adult mental health outcomes. [ 110 ] Living in an urban environment during childhood or as an adult has consistently been found to increase the risk of schizophrenia by a factor of two, [ 27 ] [ 111 ] even after taking into account drug use , ethnic group , and ...
Reelin abnormalities may also be involved in the pathogenesis of schizophrenia via a glutamate-dependent mechanism. Reelin expression deficits are seen in schizophrenia, and reelin enhances expression of AMPA and NMDA alike. [8] As such deficits in these two ionotropic glutamate receptors may be partially explained by altered reelin cascades.
In the study researchers examined hundreds of post-mortem specimen brains donated to the Lieber Institute from more than 350 people, some with schizophrenia and others without psychiatric illness.
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
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