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In severe cases, the neurological complications of pernicious anemia can lead to death – hence the name, "pernicious", meaning deadly. [citation needed] There is an increased risk of gastric cancer in those with pernicious anemia linked to the common feature of atrophic gastritis. [67] [68]
Those with autoimmune atrophic gastritis (Type A gastritis) are statistically more likely to develop gastric carcinoma (a form of stomach cancer), Hashimoto's thyroiditis, and achlorhydria. Type A gastritis primarily affects the fundus (body) of the stomach and is more common with pernicious anemia. [1]
Pernicious anemia, helicobacter pylori infection, hypothyroidism, stomach surgery, nutritional deficiencies, and long term use of medications to treat heartburn Achlorhydria and hypochlorhydria refer to states where the production of hydrochloric acid in gastric secretions of the stomach and other digestive organs is absent or low, respectively ...
Stomach cancers usually occur due to fluctuations in acidity level and may present with vague symptoms of abdominal fullness, weight loss and pain. The actual cause of stomach cancer is not known but has been linked to infection with Helicobacter pylori, pernicious anemia, Menetriere's disease, and nitrogenous preservatives in food. [4]
The stomach is an organ of the gastrointestinal tract that sits in the abdomen. [1] Tumors of the stomach are known as gastric tumors, and can be either benign or malignant (gastric cancer). These tumors arise from the cells of the gastric mucosa which lines the stomach. Typically, most gastric tumors are cancerous and not detected until a ...
Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of digestion, including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The symptoms relate to the organ affected and can include obstruction (leading to difficulty swallowing ...
In 1870, Samuel Fenwick noted that pernicious anemia causes glandular atrophy in gastritis. German surgeon Georg Ernst Konjetzny noticed that both gastric ulcer and gastric cancer are the results of gastric inflammation. Shields Warren and Willam A. Meissner described the intestinal metaplasia of the stomach as a feature of chronic gastritis. [33]
Congenital disorders of the stomach include pernicious anaemia, in which a targeted immune response against parietal cells results in an inability to absorb vitamin B12. Other common symptoms that stomach disease might cause include indigestion or dyspepsia, vomiting, and in chronic disease, digestive problems leading to forms of malnutrition.