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The drugs include Adderall, Vyvanse and generic amphetamines, such as dextroamphetamine. The link between amphetamines and psychosis isn’t new. Amphetamines increase levels of dopamine in the brain.
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
The neurotransmitters are dopamine and norepinephrine in the case of Adderall. ... Adderall can cause a heart attack — especially in those who have existing heart conditions.
In rodents and primates, sufficiently high doses of amphetamine cause dopaminergic neurotoxicity, or damage to dopamine neurons, which is characterized by dopamine terminal degeneration and reduced transporter and receptor function. [169] [170] There is no evidence that amphetamine is directly neurotoxic in humans.
These drugs show greater magnitudes of impact on dopamine levels than do dopamine reuptake inhibitors like methylphenidate. [ 62 ] [ 63 ] In addition, whereas dopamine reuptake inhibitors show a clear dose–effect ceiling in their effects on dopamine levels, dopamine releasing agents do not and have been found to maximally increase dopamine ...
When it comes to Wellbutrin vs Adderall, these two medications do have some similarities, including that they both affect the brain’s supply of norepinephrine and dopamine.
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron.
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