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South Central Illinois is a region in the southern part of Illinois; its approximate boundaries are US 50 in the south, and Illinois Highway 16 in the north. With fertile soil throughout the region, agriculture is a chief industry here. Some of the largest communities in south-central Illinois are Alton, Collinsville, Edwardsville, and Effingham.
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U.S. Route 40 (US 40) runs east–west across south central Illinois for 159.8 miles (257.2 km). US 40 enters the state from Missouri across the Poplar Street Bridge over the Mississippi River at East St. Louis concurrent with Interstate 55 (I-55) and I-64 and exits just south of State Line, Indiana, running concurrently with I-70.
Illinois Route 48 (IL 48) is an 85.38-mile (137.41 km) north–south [3] state highway with its southern terminus at Interstate 55 (I-55) and IL 127 in Raymond and its northern terminus at IL 54 east of Clinton.
The oldest segment of I-57 is a 6.2-mile (10.0 km) strip running east of Bradley to Kankakee labeled on the 1959 Illinois state highway map. [5] Two years later, a 33-mile (53 km) stretch of I-57 from Dongola north to Marion opened on September 26, 1961. [ 6 ]
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Illinois 127 overlaps Illinois Route 146 near Jonesboro, Illinois Route 149 in Murphysboro, Illinois Route 13 from Pinckneyville to Murphysboro, U.S. Route 50 in Carlyle, Illinois Route 140 near Greenville, Illinois Route 16 in Hillsboro and wrong-way with Illinois 48 at its northern terminus. (Illinois 48 is a northbound route at the same time ...
U.S. Route 52 (US 52) in the state of Illinois is a surface road that traverses the north central and eastern portions of the state. It runs from the Dale Gardner Veterans Memorial Bridge over the Mississippi River between Sabula, Iowa, and Savanna with Illinois Route 64 (IL 64) southeast to the Indiana state line near Sheldon with US 24.
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