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Carbonic acid equilibria are important for acid–base homeostasis in the human body. An amino acid is also amphoteric with the added complication that the neutral molecule is subject to an internal acid–base equilibrium in which the basic amino group attracts and binds the proton from the acidic carboxyl group, forming a zwitterion .
In computational biology, protein pK a calculations are used to estimate the pK a values of amino acids as they exist within proteins.These calculations complement the pK a values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.
The regulatory subunit dimer of PKA is important for localizing the kinase inside the cell. The dimerization and docking (D/D) domain of the dimer binds to the A-kinase binding (AKB) domain of A-kinase anchor protein (AKAP). The AKAPs localize PKA to various locations (e.g., plasma membrane, mitochondria, etc.) within the cell.
All buffering agents achieve their function because they contain an acidic group (acetate, phosphate, sulphonate ..) or a basic group (amino, pyridyl ..). A consequence of this is that they can form complexes with the biologically important ions Na +, K +, Mg 2+ and Ca 2+ and can compete for the metal ion contained in a metalloprotein. In fact ...
PARIS — If you are an American-born NBA fan, you'll be forgiven for thinking it's a waste of time for teams to play games on European soil, while altering the inner body clock of their players ...
Around a fifth of Swiss exports of goods currently go to the United States, customs data shows, making the country a more important market for Switzerland than Germany, China or France.
Why is food satisfaction important? Having a good meal is a gift that keeps giving, Dugan said. Eating food you consider healthy and satisfying is connected to other indicators of a positive life ...
When PKAs receive energy greater than E d from bombarding electrons, they are able to displace more atoms, and some of the Frenkel defects become groups of interstitial atoms with corresponding vacancies, within a few interatomic distances of each other. In the case of bombardment by fast-moving atoms or ions, groups of vacancies and ...