Search results
Results from the WOW.Com Content Network
Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash , joint pain , fever , and lymphadenopathy .
Arthus reactions (type III hypersensitivity reactions) are rarely reported after vaccination and can occur after tetanus toxoid–containing or diphtheria toxoid–containing vaccines. An Arthus reaction is a local vasculitis associated with deposition of immune complexes and activation of complement.
The mechanism by which immune complexes are pathogenic is complex and much of what we know is derived from experimental models of the Arthus reaction and serum sickness. These models support that Fc receptors play a dominant role in the response which can be augmented by the complement system via the anaphylatoxin C5a.
The immune reactions are usually referred to as an over-reaction of the immune system and they are often damaging and uncomfortable. [ 4 ] In 1963, Philip George Houthem Gell and Robin Coombs introduced a systematic classification of the different types of hypersensitivity based on the types of antigens and immune responses involved. [ 5 ]
Case reports have noted the absence of fever in serum sickness–like reactions to amoxicillin. Laboratory abnormalities include normal or mild decreases in serum C3, C4, and CH50 levels, and mild proteinuria. In contrast to true serum sickness, renal and hepatic involvement is rare.
Here are some symptoms everyone should be aware of: Rashes. You may not think of your skin as an organ, but it is — and it can be affected by inflammation just like any other organ ...
AGS can cause a range of symptoms: mild ones like a rash or hives, or more severe ones such as difficulty breathing, and even anaphylaxis, says infectious disease expert Amesh A. Adalja, M.D ...
Chronic and/or intermittent rashes which are not readily explained by history and physical exam often will benefit from further testing. Patch test. A patch test (contact delayed hypersensitivity allergy test) [17] is a commonly used examination to determine the exact cause of an allergic contact dermatitis. According to the American Academy of ...