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Overactive bladder affects approximately 11% of the population and more than 40% of people with overactive bladder have incontinence. [5] [6] Conversely, about 40% to 70% of urinary incontinence is due to overactive bladder. [7] Overactive bladder is not life-threatening, [1] but most people with the condition have problems for years. [1]
Solifenacin, sold as the brand name Vesicare [a] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). [1] [2] It may help with incontinence, urinary frequency, and urinary urgency.
Here vibegron differs from the previous overactive bladder drug mirabegron, which was known to be associated in various drug–drug interactions by inhibiting CYP2D6 or inducing CYP3A4, CYP2D6 and CYP2C9 in the liver. [13] [4] [14] [15] [16] [17]
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. [1] [2] [3] It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis.
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Trospium chloride is a muscarinic antagonist used to treat overactive bladder. [3] It has side effects typical of this class of drugs, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed.
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