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Residual anhedonia that is not well targeted by serotonergic antidepressants is hypothesized to result from inhibition of dopamine release by activation of 5-HT 2C receptors in the striatum. [82] The response to reward in the medial orbitofrontal cortex (OFC) is attenuated in depression, while lateral OFC response is enhanced to punishment. The ...
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
Reports have suggested that certain antidepressants can sometimes have weight gain as a side effect. A study recently published in the Annals of Internal Medicine examined weight changes related ...
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
Hormones can be helpful heroes, supporting the immune system and a healthy sleep-wake schedule. But they can also be culprits of frustrating body issues, like excess weight that won’t come off ...
Macrophages can release cytokines and other chemicals to cause an inflammatory response. Peripheral inflammation can induce an inflammatory response in microglia and can cause neuroinflammation. SSRIs inhibit proinflammatory cytokine production which leads to less activation of microglia and peripheral macrophages.
Magnesium can not be produced by the human body, and can only be obtained through dietary means. [3] When the amount of magnesium levels in the blood falls below the normal level (1.3 to 2.1 mEq/L), a person is experiencing hypomagnesia, or magnesium deficiency. [2]
While intimate problems can happen with any antidepressant drug, certain ones may be more likely to cause ED. This includes citalopram, sertraline, fluoxetine, paroxetine and escitalopram.