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Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [ 1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...
Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed. Statins (or HMG-CoA reductase inhibitors) are a class of medications that reduce illness and mortality in people who are at high risk of cardiovascular disease. They are the most commonly prescribed cholesterol-lowering drugs.
In studies using standard doses, statins have been found to lower LDL-C by 18% to 55%, depending on the specific statin being used. A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after ...
Milder forms may not cause any muscle symptoms, and the diagnosis is based on abnormal blood tests in the context of other problems. More severe rhabdomyolysis is characterized by muscle pain, tenderness, weakness and swelling of the affected muscles. [ 10] If the swelling is very rapid, as may happen with a crush injury after someone is ...
58260-1. Cardiac markers are biomarkers measured to evaluate heart function. They can be useful in the early prediction or diagnosis of disease. [ 1] Although they are often discussed in the context of myocardial infarction, other conditions can lead to an elevation in cardiac marker level. [ 2][ 3] Cardiac markers are used for the diagnosis ...
Simvastatin. Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [ 4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. [ 4] It is also used to decrease the risk of heart problems in those at high risk. [ 4] It is taken by mouth.
Coronary artery disease ( CAD ), also called coronary heart disease ( CHD ), ischemic heart disease ( IHD ), [ 13] myocardial ischemia, [ 14] or simply heart disease, involves the reduction of blood flow to the cardiac muscle due to build-up of atherosclerotic plaque in the arteries of the heart. [ 5][ 6][ 15] It is the most common of the ...
Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [4] For the prevention of cardiovascular disease, statins are a first-line treatment. [4] It is taken by mouth. [4] Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. [4]