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β thalassemia major (Mediterranean anemia or Cooley anemia) is caused by a β o /β o genotype. No functional β chains are produced, and thus no hemoglobin A can be assembled. This is the most severe form of β-thalassemia; β thalassemia intermedia is caused by a β + /β o or β + /β + genotype. In this form, some hemoglobin A is produced;
Treatment. Blood transfusion, possible splenectomy [ 1][ 4] Alpha-thalassemia ( α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 [ 5] and HBA2. [ 6] Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. [ 7]
Beta-thalassemia; Other names: Microcytemia, beta type [1] Beta thalassemia genetics, the picture shows one example of how beta thalassemia is inherited. The beta globin gene is located on chromosome 11. A child inherits two beta globin genes (one from each parent). Specialty: Hematology: Types: Thalassemia minor, intermediate and major [2] Causes
Casgevy, which requires administration through authorized treatment centers with experience in stem cell transplantation, will be made available to eligible patients from Aug. 7, the company said.
The brown areas contain hemosiderin. Specialty. Hematology. Hemosiderosis is a form of iron overload disorder resulting in the accumulation of hemosiderin . Types include: Transfusion hemosiderosis [ 1] Idiopathic pulmonary hemosiderosis. Transfusional diabetes [ 2][ 3] Organs affected:
The Mentzer index, described in 1973 by William C. Mentzer, [ 1] is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. [ 2][ 3] The index is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by ...
Other names. Alpha-thalassemia intermedia. Specialty. Hematology. Hemoglobin H disease, also called alpha-thalassemia intermedia, is a disease affecting hemoglobin, the oxygen carrying molecule within red blood cells. It is a form of Alpha-thalassemia which most commonly occurs due to deletion of 3 out of 4 of the α-globin genes.
H&E stain. Extramedullary hematopoiesis ( EMH or sometimes EH [1]) refers to hematopoiesis occurring outside of the medulla of the bone ( bone marrow ). [2] It can be physiologic or pathologic. Physiologic EMH occurs during embryonic and fetal development; during this time the main site of fetal hematopoiesis are liver and the spleen.