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Excessive catecholamine stimulation has a toxic effect on cardiac muscle cells which creates necrosis of the contractile units of cells similarly seen during acute myocardial infarction. [ 6 ] [ 12 ] The increased workload of cardiac muscle created by the stimulation of catecholamines, increases the need for more blood and oxygen to these ...
The symptoms of a sympathetic pheochromocytoma are related to sympathetic nervous system hyperactivity. [10] The classic triad includes headaches (likely related to elevated blood pressure, or hypertension), tachycardia/elevated heart rate, and diaphoresis (excessive sweating, particularly at night, also known as hyperhidrosis). [7]
Serotonin, being a tryptamine (non-catecholamine) involved in higher brain functions, can cause dangerous hypertension and tachycardia from its effects on the sympathetic nervous system. [23] Symptoms caused by excessive adrenergic signalling can occur alongside those of serotonergic signalling.
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Catecholamine excess Certain medicines such as tricyclic antidepressants , [ 3 ] digoxin , sympathomimetics , aminophylline [ 5 ] Chemical (electrolyte) abnormalities in the blood [ 6 ] (for example hypokalemia (low blood potassium), which can occur in those taking diuretics ("water pills") [ 7 ] and hypomagnesaemia (magnesium deficiency)).
Metirosine has been shown to suppress catecholamine synthesis and alleviate symptoms related to catecholamine excess, including hypertension, headache, tachycardia, constipation, and tremor. [12] Metirosine is primarily used to reduce these symptoms in patients with pheochromocytoma. [13]
When the breastbone (sternum) and attached ribs are sunken in enough to put excess pressure on the heart and lungs which can cause tachycardia and skipped beats. Palpitations can occur during times of catecholamine excess, such as during exercise or at times of stress. [1]
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