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[23] [13] First made in 1977, [20] ketoconazole was the first orally-active azole antifungal medication. [23] However, ketoconazole has largely been replaced as a first-line systemic antifungal medication by other azole antifungal agents, such as fluconazole and/or itraconazole , because of ketoconazole's greater toxicity, poorer absorption ...
Topical antifungal drugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus.
Bifonazole (trade name Canespor among others [1]) is an imidazole antifungal drug used in form of ointments. It was patented in 1974 and approved for medical use in 1983. [2] There are also combinations with carbamide for the treatment of onychomycosis.
Antifungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection).
The search for antifungal agents with acceptable toxicity profiles led first to the discovery of ketoconazole, the first azole-based oral treatment of systemic fungal infections, in the early 1980s. Later, triazoles fluconazole and itraconazole, with a broader spectrum of antifungal activity and improved safety profile were developed.
Ketoconazole (and other azole antifungals like itraconazole): This medication is used to treat fungal infections. The ointment you are applying to her wound has one of these medications ...
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