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Still, another form of illness called chronic refractory cough doesn’t respond to treatment. It involves cough nerves that are hypersensitive to triggers that don’t make others cough, such as ...
The health regulator concluded the company's application for the drug, gefapixant, did not meet substantial evidence of effectiveness for treating refractory chronic cough and unexplained chronic ...
Merck's (MRK) two phase III studies on gefapixant (MK-7264) for the treatment of refractory or unexplained chronic cough meet the primary efficacy endpoints.
The prevalence of chronic cough in many communities in Europe and the U.S. is 9–33% of the population. Chronic cough is three times more common in those who smoke compared to people who never smoke. [1] The most important risk factors for chronic cough are tobacco smoking and working in a dusty job. [30]
It is commonly available in cough syrups and also as sustained-release tablets. Mucolytics can dissolve thick mucus and are usually used to help relieve respiratory difficulties. They do this by breaking down the chemical bonds between molecules in the mucus. [5] This in turn can lower the viscosity by altering the mucin-containing components.
Approved indication for dihydrocodeine is the management of moderate to moderately severe pain as well as coughing and shortness of breath. As is the case with other drugs in this group, the antitussive dose tends to be less than the analgesic dose, and dihydrocodeine is a powerful cough suppressant like all other members of the immediate codeine family (see below) and their cousins ...
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