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The inner mitochondrial membrane is both an electrical insulator and chemical barrier. Sophisticated ion transporters exist to allow specific molecules to cross this barrier. There are several antiport systems embedded in the inner membrane, allowing exchange of anions between the cytosol and the mitochondrial matrix. [7]
The inner membrane is home to around 1/5 of the total protein in a mitochondrion. [31] Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered in cow hearts in 1942, and is usually characteristic of mitochondrial and bacterial plasma membranes. [32]
NADH is oxidized into NAD +, H + ions, and electrons by an enzyme. FADH 2 is also oxidized into H + ions, electrons, and FAD.As those electrons travel farther through the electron transport chain in the inner membrane, energy is gradually released and used to pump the hydrogen ions from the splitting of NADH and FADH 2 into the space between the inner membrane and the outer membrane (called ...
The TIMM50 gene is located on the q arm of chromosome 19 in position 13.2 and spans 13,373 base pairs. [6] The gene produces a 39.6 kDa protein composed of 353 amino acids. [10] [11] This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex, which mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The mitochondrial matrix contains the mitochondrial DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions. [1]
The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. [10] The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation.
Then they are transported across the inner mitochondrial membrane into the matrix and converted into the acetyl CoA to enter the citric acid cycle. [7] [8] Apoptotic components released from the intermembrane space of a mitochondrion. The respiratory chain in the inner mitochondrial membrane carries out oxidative phosphorylation.
30055 Ensembl ENSG00000099800 ENSMUSG00000020219 UniProt Q9Y5L4 P62075 RefSeq (mRNA) NM_012458 NM_013895 RefSeq (protein) NP_036590 NP_038923 Location (UCSC) Chr 19: 2.43 – 2.43 Mb Chr 10: 80.74 – 80.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene. Function ...