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Herpesviruses also cause cancer in animals, especially leukemias and lymphomas. [13] Human T cell lymphotropic virus was the first human retrovirus discovered by Robert Gallo and colleagues at NIH. [20] The virus causes Adult T-cell leukemia, a disease first described by Takatsuki and colleagues in Japan [21] and other neurological diseases ...
It was suggested that such types of viruses could cause cancer by introducing new genes into the genome. Genetic analysis of mice infected with Friend virus confirmed that retroviral integration could disrupt tumor suppressor genes, causing cancer. [51] Viral oncogenes were subsequently discovered and identified to cause cancer.
The herpes simplex virus type 1 (HSV-1) mutant 1716 lacks both copies of the ICP34.5 gene, and as a result is no longer able to replicate in terminally differentiated and non-dividing cells but will infect and cause lysis very efficiently in cancer cells, and this has proved to be an effective tumour-targeting strategy.
[4] [5] Most of these viruses are very common and typically asymptomatic in most human populations studied. [6] [7] BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients, [8] [9] JC virus with progressive multifocal leukoencephalopathy, [10] and Merkel cell virus with Merkel cell cancer. [11]
BK virus has a wide spectrum of tissue and cell type tropism. The virus is detected in urinary tract system, salivary gland cells, peripheral blood leukocytes, pancreatic cells, vascular endothelial cells. [18] BKV has been identified in upper respiratory tract and tonsils as well as in fetus cells. [13]
This is an accepted version of this page This is the latest accepted revision, reviewed on 5 January 2025. Medical condition Kidney cancer Other names Renal cancer Micrograph showing the most common type of kidney cancer (clear cell renal cell carcinoma). H&E stain. Specialty Oncology nephrology Urology Symptoms Blood in the urine, lump in the abdomen, back pain Usual onset After the age of 45 ...
A virus that can cause cancer is called an oncovirus. These include human papillomavirus ( cervical carcinoma ), Epstein–Barr virus ( B-cell lymphoproliferative disease and nasopharyngeal carcinoma ), Kaposi's sarcoma herpesvirus ( Kaposi's sarcoma and primary effusion lymphomas ), hepatitis B and hepatitis C viruses ( hepatocellular ...
Ulceration can cause bleeding that can lead to symptoms such as coughing up blood (lung cancer), anemia or rectal bleeding (colon cancer), blood in the urine (bladder cancer), or abnormal vaginal bleeding (endometrial or cervical cancer). Although localized pain may occur in advanced cancer, the initial tumor is usually painless.