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Ultrafiltration (UF) is a variety of membrane filtration in which forces such as pressure or concentration gradients lead to a separation through a semipermeable membrane. Suspended solids and solutes of high molecular weight are retained in the so-called retentate, while water and low molecular weight solutes pass through the membrane in the ...
In renal physiology, ultrafiltration occurs at the barrier between the blood and the filtrate in the glomerular capsule (Bowman's capsule) in the kidneys. As in nonbiological examples of ultrafiltration , pressure (in this case blood pressure ) and concentration gradients lead to a separation through a semipermeable membrane (provided by the ...
The pedicels increase the surface area of the cells enabling efficient ultrafiltration. [8] Pedicels of podocytes interdigitating to create numerous filtration slits around glomerular capillaries in 5000x electron micrograph. Podocytes secrete and maintain the basement membrane. [3]
Ultrafiltration removes particles higher than 0.005-2 μm and operates within a range of 70-700kPa. [4] Ultrafiltration is used for many of the same applications as microfiltration. Some ultrafiltration membranes have also been used to remove dissolved compounds with high molecular weight, such as proteins and carbohydrates.
Ultrafiltration concentrates a protein solution using selective permeable membranes. The function of the membrane is to let the water and small molecules pass through while retaining the protein. The solution is forced against the membrane by mechanical pump, gas pressure, or centrifugation.
B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa C. Podocytes: 1. enzymatic and structural proteins 2. filtration slit 3. diaphragma. The main function of the glomerulus is to filter plasma to produce glomerular filtrate, which passes down the length of the nephron tubule to form urine.
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
Staverman's reflection coefficient, σ, is a unitless constant that is specific to the permeability of a membrane to a given solute. [6] The Starling equation, written without σ, describes the flow of a solvent across a membrane that is impermeable to the solutes contained within the solution. [7]