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In the management of Parkinson's disease, due to the chronic nature of Parkinson's disease (PD), a broad-based program is needed that includes patient and family education, support-group services, general wellness maintenance, exercise, and nutrition. At present, no cure for the disease is known, but medications or surgery can provide relief ...
An area of the brain which degenerates in Parkinson's disease, called the substantia nigra pars compacta, is visualized as two dark brown bands in the lower half of the image. Cell-based therapies for Parkinson's disease include various investigational procedures which transplant specific populations of cells into the brains of people with ...
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L-DOPA, a treatment for Parkinson’s disease, may induce dyskinesia. Parkinson’s disease is a neurodegenerative disorder caused by the death of dopamine-producing neurons.
Parkinson's typically manifests in individuals over 60, with about one percent affected. In those younger than 50, it is termed "early-onset PD". No cure for Parkinson's is known, and treatment focuses on alleviating symptoms. Initial treatment typically includes L-DOPA, MAO-B inhibitors, or dopamine agonists.
COMT inhibitors are indicated for the treatment of Parkinson's disease in combination with levodopa and an aromatic L-amino acid decarboxylase inhibitor (e.g. carbidopa or benserazide). The therapeutic benefit of using a COMT inhibitor is based on its ability to prevent the methylation of levodopa to 3- O -methyldopa , thus increasing the ...
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