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Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. [8] GOLD 2024 defined COPD as a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea or shortness of breath, cough, sputum production or exacerbations) due to abnormalities of the airways (bronchitis ...
Many people with chronic obstructive pulmonary disease have a low partial pressure of oxygen in the blood and high partial pressure of carbon dioxide.Treatment with supplemental oxygen may improve their well-being; alternatively, in some this can lead to the adverse effect of elevating the carbon dioxide content in the blood (hypercapnia) to levels that may become toxic.
COPD is defined as a forced expiratory volume in 1 second divided by the forced vital capacity (FEV1/FVC) that is less than 0.7 (or 70%). [8] The residual volume, the volume of air left in the lungs following full expiration, is often increased in COPD, as is the total lung capacity, while the vital capacity remains relatively normal.
Emphysema is a respiratory disease of the lower respiratory tract. [7] It is commonly caused by tobacco smoking but some people are affected who have never smoked. [ 14 ] The presence of emphysema is a clear risk factor for lung cancer, made stronger in those who smoke.
These effects contribute to the pathogenesis of diseases such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). In the central nervous system, high levels of oxygen can cause seizures, which are a significant risk in hyperbaric oxygen therapy if not carefully monitored. [2]
The normal relaxed state of the lung and chest is partially empty. Further exhalation requires muscular work. Inhalation is an active process requiring work. [4] Some of this work is to overcome frictional resistance to flow, and part is used to deform elastic tissues, and is stored as potential energy, which is recovered during the passive process of exhalation, Tidal breathing is breathing ...
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