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  2. List of signalling pathways - Wikipedia

    en.wikipedia.org/wiki/List_of_signalling_pathways

    In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells. Akt/PKB signalling pathway

  3. Akt/PKB signaling pathway - Wikipedia

    en.wikipedia.org/wiki/Akt/PKB_signaling_pathway

    The Akt-PI3K pathway is essential for cell survival as activated Akt influences many factors involved in apoptosis, either by transcription regulation or direct phosphorylation. [ 5 ] In the nucleus, Akt inhibits transcription factors that promote the expression of cell death genes, and enhances transcription of anti-apoptotic genes.

  4. PI3K/AKT/mTOR pathway - Wikipedia

    en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway

    Akt is an AGC-family kinase and a central, integral signaling node of the PAM pathway. There are three Akt isozymes, Akt1, Akt2 and Akt3. There are three Akt isozymes, Akt1, Akt2 and Akt3. Small-molecule inhibitors of Akt1 could be especially useful to target tumors with a high prevalence of Akt1 E17K activating mutations, which is observed in ...

  5. Protein kinase B - Wikipedia

    en.wikipedia.org/wiki/Protein_Kinase_B

    Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.

  6. Serine/threonine-specific protein kinase - Wikipedia

    en.wikipedia.org/wiki/Serine/threonine-specific...

    Three human akt genes exist. All three Akt kinases regulate cell proliferation and Akt2 is particularly important for insulin actions in cells. A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.11.1: Pelle: is a serine/threonine kinase that can phosphorylate itself, and also Tube and Toll. EC 2.7.11.11: Protein kinase A

  7. AKT3 - Wikipedia

    en.wikipedia.org/wiki/AKT3

    AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis , tumorigenesis , as well as glycogen synthesis and glucose uptake.

  8. Cell signaling - Wikipedia

    en.wikipedia.org/wiki/Cell_signaling

    In biology, cell signaling (cell signalling in British English) is the process by which a cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Typically, the signaling process involves three components: the signal, the receptor, and the effector.

  9. Mitogen-activated protein kinase - Wikipedia

    en.wikipedia.org/wiki/Mitogen-activated_protein...

    Fungi also have a pathway reminiscent of mammalian JNK/p38 signaling. This is the Hog1 pathway: activated by high osmolarity (in Saccharomyces cerevisiae) or a number of other abiotic stresses (in Schizosaccharomyces pombe). The MAP2 kinase of this pathway is called Pbs2 (related to mammalian MKK3/4/6/7), the dedicated MAP3 kinases involved in ...