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Dr. Donna Eleese (Teri Hatcher, age 19 / Mimi Kuzyk, age 45) – Born Donna Wojohowitz, she is Sam's wife and director of Project Quantum Leap in her husband's absence. Originally, Donna was not involved with the project, until Sam altered history, thus ensuring her involvement and getting rid of the Committee (see below) .
Ellen Craig was Dr. Mark Craig's long-suffering wife. (She was played by Bonnie Bartlett, off-screen wife to William Daniels, who portrayed Mark Craig.) Though only a minor character initially, she proved popular with viewers and she became a series regular at the beginning of season 4 and was featured on the opening credits beginning at season 5.
At some point during his military service, he met and befriended Dr. Manning's husband, who was also named Jeff. The character was reintroduced in a brief scene during the season 1 finale where he reveals that he is now divorced from his wife Lisa. Dr. Nina Shore (Patti Murin) is a Attending Physician in Pathology who briefly dates Dr. Will ...
Dr. Caitlin Snow (portrayed by Danielle Panabaker; main: seasons 1–9) is a bioengineer who works at S.T.A.R. Labs, the daughter of scientists Thomas Snow and Carla Tannhauser, and the wife of Ronnie Raymond. She temporarily shares her body with an alter-ego named Killer Frost, and is later temporarily "replaced" with a new personality named ...
Played by Damian Lewis, Nicholas Brody is the husband of Jessica Brody and father to Dana and Chris. He is an ex-Marine who was captured by al-Qaeda and held as a POW for eight years in Iraq. Brody, after years of brutal treatment, becomes sympathetic to Abu Nazir's cause during his captivity and agrees to return to the United States as a ...
Melinda Page Hamilton as Connie Nunn, a cold-blooded and murderous agent of the William J. Burns International Detective Agency, who believes that Seth Davenport killed her strikebreaking husband. Joe Adler as D. L. Sullivan, a reporter for the town's local newspaper, who nurses literary ambitions and comes to sympathize with the Davenports ...
Brian Ach/Getty Images for Urban Zen Scott Hamilton has received support from wife Tracie Hamilton as he battled brain cancer numerous times. Before the couple started dating, Scott made a name ...
Kellie Newmark (Cynthia Watros) – Drew's childhood friend. She has had a crush on Drew since high school but never told him. She was married but her husband cheated on her with her sister. Her mother is an alcoholic and leaves her father, eventually hooking up with Lewis. After Kate leaves, Drew realizes that he loves Kellie.