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  2. Gliclazide - Wikipedia

    en.wikipedia.org/wiki/Gliclazide

    Gliclazide selectively binds to sulfonylurea receptors (SUR-1) on the surface of the pancreatic beta-cells. It was shown to provide cardiovascular protection as it does not bind to sulfonylurea receptors (SUR-2A) in the heart. [17] This binding effectively closes these K + ion channels. This decreases the efflux of potassium from the cell which ...

  3. Sulfonylurea - Wikipedia

    en.wikipedia.org/wiki/Sulfonylurea

    Drugs that potentiate or prolong the effects of sulfonylureas and therefore increase the risk of hypoglycemia include acetylsalicylic acid and derivatives, allopurinol, sulfonamides, and fibrates. Drugs that worsen glucose tolerance , contravening the effects of antidiabetics, include corticosteroids , isoniazid , oral contraceptives and other ...

  4. Glibenclamide - Wikipedia

    en.wikipedia.org/wiki/Glibenclamide

    The medication, a sulfonylurea, works by binding to and inhibiting the ATP-sensitive potassium channels (K ATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1) [11] in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening voltage-dependent calcium Channels. [12]

  5. Hyperinsulinemic hypoglycemia - Wikipedia

    en.wikipedia.org/wiki/Hyperinsulinemic_hypoglycemia

    Management of hypoglycemia due to treatment of type 2 diabetes is similar, and the dose of the oral hypoglycemic agent may need to be reduced. Reversal and prevention of hypoglycemia is a major aspect of the management of type 1 diabetes. Hypoglycemia due to drug overdose or effect is supported with extra glucose until the drugs have been ...

  6. Sitagliptin/metformin - Wikipedia

    en.wikipedia.org/wiki/Sitagliptin/metformin

    In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...

  7. Diabetes medication - Wikipedia

    en.wikipedia.org/wiki/Diabetes_medication

    Sulfonylureas are useful only in type 2 diabetes, as they work by stimulating endogenous release of insulin. They work best with patients over 40 years old who have had diabetes mellitus for under ten years. They cannot be used with type 1 diabetes, or diabetes of pregnancy. They can be safely used with metformin or glitazones.

  8. Get orthopedic slide-on shoes up to 50% off during Cyber Monday

    www.aol.com/lifestyle/get-orthopedic-slide-on...

    Kizik makes some of the best shoes our editors have tested for those who have arthritic feet.The Kizik Athens are easy to slide into and have the love of more than 2,500 reviewers. And during ...

  9. Drug titration - Wikipedia

    en.wikipedia.org/wiki/Drug_titration

    Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]