Search results
Results from the WOW.Com Content Network
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
In yeast, roundworms, and fruitflies, sir2 is the name of one of the sirtuin-type proteins (see table below). [16] Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria. [2]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Pages for logged out editors learn more
PottersWheel is a MATLAB toolbox for mathematical modeling of time-dependent dynamical systems that can be expressed as chemical reaction networks or ordinary differential equations (ODEs). [1] It allows the automatic calibration of model parameters by fitting the model to experimental measurements.
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases.
Octave programs consist of a list of function calls or a script. The syntax is matrix-based and provides various functions for matrix operations. It supports various data structures and allows object-oriented programming. [26] Its syntax is very similar to MATLAB, and careful programming of a script will allow it to run on both Octave and ...
The sirtuins mainly seem to be involved in regulating transcription through deacetylating histones and altering nucleosome structure. [78] However, non-histone proteins can be deacetylated by sirtuins as well. These activities of sirtuins are particularly interesting because of their importance in the regulation of aging. [79] [80]
CobB is a bacterial protein that belongs to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases. [2] [3] To further this, CobB is found in the Sir2 Family protein deacetylase, which is in control of energy metabolism, chemotaxis, and DNA supercoiling in many bacteria. [4]