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Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. [ 1 ] [ 2 ] It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition.
[3] [4] On CT scans, leukoaraiosis appears as hypodense periventricular white-matter lesions. [ 5 ] The term "leukoaraiosis" was coined in 1986 [ 6 ] [ 7 ] by Hachinski , Potter, and Merskey as a descriptive term for rarefaction ("araiosis") of the white matter, showing up as decreased density on CT and increased signal intensity on T2/FLAIR ...
Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system.It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) [4] [5] [6] that maps to chromosome 17q21.
Periventricular leukomalacia, the death of brain tissue, caused by lack of oxygen; Peter Van Loan, a Canadian politician; Pike County Airport in Pikeville, Kentucky, IATA Code; Postal Officers' Union, Finland; Premier Volleyball League, a professional volleyball league in the Philippines
Periventricular means around the ventricle and may refer to: Periventricular leukomalacia , a disease characterized by the death of the white matter near the cerebral ventricles Periventricular nucleus , a composite structure of the hypothalamus
Spastic quadriplegia can be caused by a condition known as periventricular leukomalacia which results in the formation of lesions and holes in the white matter of the brain. [citation needed] Prior to the 26th week of maturation, the fetal brain is particularly susceptible to various toxins whose effects can ultimately hinder normal development.
A CT of leukoencephalopathy. Leukoencephalopathy (leukodystrophy-like diseases) is a term that describes all of the brain white matter diseases, whether their molecular cause is known or unknown. [1]
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