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Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.
Sterol+Regulatory+Element+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Brown and Goldstein Lab Archived 2009-05-26 at the Wayback Machine. Cholesterol Synthesis Archived 2017-07-04 at the Wayback Machine - has some good regulatory details; Protein Data Base (PDB), Sterol Regulatory Element ...
The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (sterol regulatory element-binding protein 1 and 2). [45] In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP cleavage-activating protein) and INSIG-1.
235623 Ensembl ENSG00000114650 ENSMUSG00000032485 UniProt Q12770 Q6GQT6 RefSeq (mRNA) NM_012235 NM_001320044 NM_001001144 NM_001103162 RefSeq (protein) NP_001306973 NP_036367 NP_001001144 NP_001096632 Location (UCSC) Chr 3: 47.41 – 47.48 Mb Chr 9: 110.16 – 110.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sterol regulatory element-binding protein cleavage-activating protein ...
Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (sterol regulatory element-binding protein-1 and -2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL ...
SREBP cleavage-activating protein (SCAP), which regulates transcription of genes with sterol response elements by proteolytically activating sterol regulatory element-binding proteins (SREBPs). This was the second SSD-containing protein to be discovered. 7-dehydrocholesterol reductase (7DHCR), involved in the last step of cholesterol biosynthesis.
Salk Institute researchers have identified a key protein that may help users of GLP-1 drugs such as Ozempic and Wegovy maintain muscle mass while losing weight.
LXRs regulate fatty acid synthesis by modulating the expression of sterol regulatory element binding protein-1c (SREBP-1c). [19] [20] LXRs also regulate lipid homeostasis in the brain. LXRα and LXRβ double knockout mice develop neurodegenerative changes in brain tissue. [21] LXRβ knockout mice results in adult-onset motor neuron degeneration ...