Search results
Results from the WOW.Com Content Network
In some cases, cleft palate is caused by syndromes that also cause other problems: Stickler syndrome can cause cleft lip and palate, joint pain, and myopia. [40] [41] Loeys–Dietz syndrome can cause cleft palate or bifid uvula, hypertelorism, and aortic aneurysm. [42]
Cleft palate alone (CP) results in a prevalence rate of 5.5 to 6.6 per 10,000 births (Forrester & Merz, 2004). Cleft of the lip, palate, or both is one of the most common congenital abnormalities and has a birth prevalence rate ranging from 1/1000 to 2.69/1000 amongst different parts of the world (McLeod, Saeed, & Arana- Urioste, 2004).
Maxillary hypoplasia is the most common secondary deformity that results from cleft lip and cleft palate. Because of the subjective nature of the diagnosis, the incidence of maxillary hypoplasia in people with cleft lip and palate varies between 15-50%. It is estimated that 25-50% of these patients require surgical intervention. [7]
Within craniofacial disorders and abnormalities, orofacial clefts, and specifically cleft lip (CL) and cleft palate (CP) are the most common in humans. [9] Occurrences of CL/P are most often (around seventy percent of cases) isolated and nonsyndromic, meaning they are not associated with a syndrome or inherited genetic conditions.
Feeding problems, impaired speech, and hearing loss are symptoms of a submucous cleft palate. [4] Furthermore, approximately 15% of VWS cases with orofacial clefts, in the absence of prominent lip pits, cannot be easily distinguished from non-syndromic forms of orofacial clefting. [ 7 ]
Complications may include breathing problems, problems seeing, cleft palate, and hearing loss. [5] Those affected generally have normal intelligence. [5] TCS is usually autosomal dominant. [5] More than half the time it occurs as a result of a new mutation rather than being inherited. [5] The involved genes may include TCOF1, POLR1C, or POLR1D. [5]
Persons with Pierre Robin sequence (PRS) are at greater risk for hearing impairment than persons with cleft lip and/or palate without PRS. One study showed an average of 83% hearing loss in PRS, compared to 60% in cleft individuals without PRS (Handzic et al., 1995). Similarly, PRS individuals typically exhibit conductive, bilateral hearing ...
Holoprosencephaly-ectrodactyly-cleft lip/palate syndrome, also simply known as Hartsfield syndrome, is a rare genetic disorder characterized by the presence of variable holoprosencephaly, ectrodactyly, cleft lip and palate, alongside generalized ectodermal abnormalities.