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Methylphosphonyl dichloride (DC) or dichloro is an organophosphorus compound. It has commercial application in oligonucleotide synthesis, [1] but is most notable as being a precursor to several chemical weapons agents. It is a white crystalline solid that melts slightly above room temperature. [2]
Methyldichlorophosphine is produced by alkylation of phosphorus trichloride with methyl iodide followed by reduction of the resulting phosphonium salt with iron powder: [2] [3]
Methylphosphonic acid is an organophosphorus compound with the chemical formula CH 3 P(O)(OH) 2.The phosphorus center is tetrahedral and is bonded to a methyl group, two OH groups and an oxygen.
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[1] [2] [3] Alprostadil is a prostaglandin vasodilator that allows more blood to flow into the area by relaxing the smooth muscle in the blood vessels of the penis. [ 3 ] [ 7 ] Papaverine is a smooth muscle relaxant that acts by increasing blood flow to the penis.
Dimethyl methylphosphonate can be prepared from trimethyl phosphite and a halomethane (e.g. iodomethane) via the Michaelis–Arbuzov reaction. [2]Dimethyl methylphosphonate is a schedule 2 chemical as it may be used in the production of chemical weapons.
[1] [2] However, aluminum chloride often induces diarylation; a cleaner catalyst for monoarylation is stannic chloride. [2] The compound is an intermediate for the synthesis of other chemicals for instance dimethylphenylphosphine: C 6 H 5 PCl 2 + 2 CH 3 MgI → C 6 H 5 P(CH 3) 2 + 2 MgICl. Many tertiary phosphines can be prepared by this route. [3]
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