Search results
Results from the WOW.Com Content Network
The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands. [1] [4] Production of cortisol begins at week 8 of fetal ...
Schematic diagram of the androgen biosynthesis via the canonical, backdoor, and 11-oxyback door pathways ... Added the 11-oxy backdoor pathway is also important in ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [ 7 ] [ 8 ] [ 9 ] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen , i.e., it binds to the progesterone receptors .
Therefore, androstanediol can be used a marker of the backdoor pathway of DHT synthesis. [11] Spectrometric studies identify androsterone as the main backdoor androgen in the human male fetus. Circulating levels are sex dependent, DHT being essentially absent in the female, in which titres of backdoor intermediates also are very low. [12]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
5α-Reductase (1, 2, 3) – androgen and neurosteroid synthesis, progestogen metabolism; 5β-Reductase – androgen and progestogen metabolism, neurosteroid synthesis; Conjugation (and deconjugation) Glucuronosyltransferase – steroid metabolism [6] Glucuronidase (β-glucuronidase) – steroid synthesis [7]
Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth. [25] [26] The decreased enzyme activity of CYP17A1 is related to infertility due to hypogonadotropic hypogonadism. In females, folliculogenesis is arrested, while in males, testicular ...