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Protamine sulfate is a medication that is used to reverse the effects of heparin. [3] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery. [3] [4] It is given by injection into a vein. [3] The onset of effects is typically within five ...
Adverse effects include increased pulmonary artery pressure and decrease peripheral blood pressure, myocardial oxygen consumption, cardiac output, and heart rate. [9] Protamine sulfate is an antidote for heparin overdose, but severe allergy may occur. [10]
Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Because protamine is a fast-acting drug, it is typically given slowly to allow for monitoring of possible reactions. [12] The first step in management of a protamine reaction is to immediately stop the protamine infusion. Corticosteroids are used for all types of protamine reactions. Chlorphenamine is used for type II (anaphylactic) reactions ...
Sheryl Crow had once been a proud Tesla owner, even interfacing with Elon Musk on social media about her car. But whatever support the environmentally minded singer formerly had for the EVs has ...
Structure formula of one of the many sulfation patterns of the heparan sulfate subunit. Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. [1] It occurs in a proteoglycan (HSPG, i.e. Heparan Sulfate ProteoGlycan) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins.
A new study found that omega-3 slowed biological aging by up to four months, with vitamin D and strength training boosting the effects: A neurologist explains.
Patients who have taken pentosan polysulfate orally report a variety of side effects, primarily gastrointestinal complaints such as diarrhea, heartburn, and stomach pain. [4] Hair loss, headache, rash, and insomnia have also been reported. [4] Due to Elmiron's anticoagulant effects, some patients report bruising more easily.