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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes
In the 1960s scientists recognized that phosphates in water caused eutrophication. [23] There was disagreement at that time about whether water with high phosphate came to have the chemical because of somehow being polluted with it. [23] By the 1970s it was established that high phosphate levels in water were a consequence of pollution. [23]
Side effects may include increased bowel gas, abdominal pain, and nausea. [3] Rare but serious side effects may include an abnormal heartbeat, seizures, and kidney problems. [8] Use appears to be safe during pregnancy. [9] [3] It is classified as an osmotic laxative: [4] It works by increasing the amount of water in the stool. [5]
As magnets affect water to a small degree, and water containing ions is more conductive than purer water, magnetic water treatment is an example of a valid scientific hypothesis that failed experimental testing and is thus disproven. Any products claiming to utilize magnetic water treatment are absolutely fraudulent. [1]
After weighing its questionable benefits against its possible adverse effects (including nausea, vomiting, muscle weakness and prolonged duration of action of nondepolarizing neuromuscular blocking agents [32]), experts no longer recommend the use of prophylactic dantrolene prior to trigger-free general anesthesia in MH-susceptible patients. [30]
Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. Adverse effects may also be caused by drug interaction. This ...
Triclosan was used as a hospital scrub in the 1970s. Prior to its change in regulatory status in the EU and US, it had expanded commercially and was a common ingredient in soaps (0.10–1.00%), shampoos, deodorants, toothpastes, mouthwashes, cleaning supplies, and pesticides. [3]
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