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1544 13077 Ensembl ENSG00000140505 ENSMUSG00000032310 UniProt P05177 P00186 RefSeq (mRNA) NM_000761 NM_009993 RefSeq (protein) NP_000752 NP_034123 Location (UCSC) Chr 15: 74.75 – 74.76 Mb Chr 9: 57.58 – 57.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the ...
A classical example includes anti-epileptic drugs, such as phenytoin, which induces CYP1A2, CYP2C9, CYP2C19, and CYP3A4. Effects on P450 isozyme activity are a major source of adverse drug interactions, since changes in P450 enzyme activity may affect the metabolism and clearance of various drugs. For example, if one drug inhibits the P450 ...
Parts of a typical chromosome: (1) Chromatid (2) Centromere (3) Short (p) arm (4) Long (q) arm. In genetics, a locus (pl.: loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. [1]
CYP1A1 also metabolizes polyunsaturated fatty acids into signaling molecules that have physiological as well as pathological activities. CYP1A1 has monoxygenase activity in that it metabolizes arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides, primarily ...
196 11622 Ensembl ENSG00000106546 ENSMUSG00000019256 UniProt P35869 P30561 RefSeq (mRNA) NM_001621 NM_013464 NM_001314027 RefSeq (protein) NP_001612 NP_001300956 NP_038492 Location (UCSC) Chr 7: 16.92 – 17.35 Mb Chr 12: 35.55 – 35.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, AH receptor, or as the dioxin ...
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The latter hydroxy metabolites can be converted by an unidentified cytochrome P450 enzyme to maresin like-1 (Mar-L1) and Mar-L2 by omega oxidation; alternatively, DHA may be first metabolized to 22-hydroxy-DHA by CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, or CYP3A4 and then metabolized through the cited epoxide-forming pathways to Mar-L1 and MaR ...
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