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DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity for A 2 adenosine receptors, in contrast to the A 1 subtype receptors. [1] DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist NECA.
Ergotamine/caffeine, sold under the brand name Cafergot among others, is a fixed-dose combination medication used for the treatment of migraine. It contains ergotamine, as the tartrate, an alpha adrenergic blocking agent; and caffeine, a cranial vasoconstrictor. [3] Ergotamine/caffeine is available as a generic medication.
It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. [10] [11] [13] An oral formulation has also been developed. [13]Due to its peripheral selectivity, difelikefalin lacks the central side effects like sedation, dysphoria, and hallucinations of previous KOR-acting analgesics such as pentazocine and phenazocine.
Treatment of mild caffeine intoxication is directed toward symptom relief; severe intoxication may require peritoneal dialysis, hemodialysis, or hemofiltration. [3] Control of caffeine intake requires awareness of the caffeine content of caffeinated beverages, over-the-counter drugs, and other sources of caffeine in the diet.
This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other. 2C-B: MDMA: Nexus ...
Antibiotics by class Generic name Brand names Common uses [4] Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and ...
Istradefylline, sold under the brand name Nourianz, is a medication used as an add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes. [ 2 ] [ 3 ] [ 4 ] Istradefylline reduces "off" periods resulting from long-term treatment with the antiparkinson drug levodopa . [ 2 ]
Activation of a nitric oxide-cGMP pathway may be responsible for some of the behavioral effects of paraxanthine that differ from those associated with caffeine. [ 13 ] Paraxanthine is a competitive nonselective phosphodiesterase inhibitor [ 14 ] which raises intracellular cAMP , activates PKA , inhibits TNF-alpha [ 15 ] [ 16 ] and leukotriene ...