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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
The distributions of other subclades of O2-M122 in the Philippines were sporadic, but it may be noted that O2a1b-JST002611 was observed in 6/24 = 25% of a sample of Ivatan and 1/31 = 3.2% of a sample from the Visayas, O2a2a1a2-M7 was observed in 1/6 = 17% of a sample from North Luzon, 1/55 = 1.8% of a sample from South Luzon, and 1/31 = 3.2% of ...
Pages in category "History of the Philippines (1986–present)" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes .
The history of the Philippines dates from the earliest hominin activity in the archipelago at least by 709,000 years ago. [1] Homo luzonensis, a species of archaic humans, was present on the island of Luzon [2] [3] at least by 134,000 years ago. [4] The earliest known anatomically modern human was from Tabon Caves in Palawan dating about 47,000 ...
This list of conflicts in the Philippines is a timeline of events that includes pre-colonial wars, Spanish–Moro conflict, Philippine revolts against Spain, battles, skirmishes, and other related items that have occurred in the Philippines' geographical area.
Year Date Event Source c.200 AD The Maitum Jars are anthropomorphic jars that were depicting children (head is the lead of the jar with ears and the body was the jar itself with hands and feet as the handle) with perforations in red and black colors, had been used as a secondary burial jars in Ayub Cave, Pinol, Maitum Sarangani province, each of the jars had a "facial expression".