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Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [1] [2] It is used together with a diabetic diet and exercise. [1] [2] It is not indicated for use by itself in type 1 diabetes. [1] [2] It is taken by mouth.
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Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
Thaitone is a color scheme designed to follow colors used in traditional Thai art.It was compiled by Pairoj Pittayamatee, and is the result of ten years study about the traditional color making and using in Thailand art history for his master's and doctoral degrees at Silpakorn University.
[32] [33] Liraglutide was approved by the FDA in 2019, for treatment of children ten years or older with type 2 diabetes, making it the first non-insulin drug approved to treat type 2 diabetes in children since metformin was approved in 2000. [34] Novo Nordisk made deals with generic manufacturers to enter the United States market in 2024.
Tirzepatide [12] is an antidiabetic medication used for the treatment of type 2 diabetes [9] [13] [14] [15] and for weight loss. [10] [16] Tirzepatide is administered via subcutaneous injections (under the skin).
They will start a clinical trial with healthy volunteers at Brigham and Women’s Hospital (BWH) within the next few months to determine whether xenon gas could have similar benefits in humans.
The Phase paint schemes have been used on most passengers equipment – locomotives, passenger cars, and trainsets – as well as some non-passenger cars and non-revenue equipment. Phase schemes generally have red, white, and blue on the sides of equipment, with black or gray sections around the wheels and roof to hide grime. [5]