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The normal range of GFR, adjusted for body surface area, is 100–130 average 125 (mL/min)/(1.73 m 2) in men and 90–120 (mL/min)/(1.73 m 2) in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 (mL/min)/(1.73 m 2 ) until 2 years of age in both sexes, and then it progressively decreases.
The normal range of GFR, adjusted for body surface area, is 100–130 average 125 mL/min/1.73m 2 in men and 90–120 ml/min/1.73m 2 in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 mL/min/1.73 m 2 until 2 years of age in both sexes, and then it progressively decreases. After age 40, GFR decreases ...
S and V differ markedly between small vs. large people and between men and women. A man and a woman of the same S will have similar levels of GFR, but their values for V may differ by 15-20%. Because standardized Kt/V incorporates residual renal function into the calculations, it makes the assumption that kidney function should scale by V.
where C is the concentration [mol/m 3]; t is the time [s]; K is the clearance [m 3 /s]; V is the volume of distribution [m 3]; From the above definitions it follows that is the first derivative of concentration with respect to time, i.e. the change in concentration with time.
Typically, in an adult human, the net filtration pressure is 10mmHg and Kf 12.5mL/min/mmHg, giving a glomerular filtration rate (GFR) of 125mL/min. A decrease in Kf due to reduced number of glomeruli or reduced permeability will reduce the GFR at a given filtration pressure [3]
The normal serum creatinine (sCr) varies with the subject's body muscle mass and with the technique used to measure it. For the adult male, the normal range is 0.6 to 1.2 mg/dl, or 53 to 106 μmol/L by the kinetic or enzymatic method, and 0.8 to 1.5 mg/dl, or 70 to 133 μmol/L by the older manual Jaffé reaction.
Kidneys were once popularly regarded as the seat of the conscience and reflection, [58] [59] and a number of verses in the Bible (e.g. Ps. 7:9, Rev. 2:23) state that God searches out and inspects the kidneys, or "reins", of humans, together with the heart.
Normal kidney function measured by creatinine clearance varies in different populations based on age, gender, race, fluid balance, and other factors, but also can be affected by diseases themselves. [1] This makes it challenging to assign an objective number or scale to kidney function.
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