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The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). [2] The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules. [3]
The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. Sinusoids display a discontinuous, fenestrated endothelial cell lining. The endothelial cells have no basement membrane and are separated from the hepatocytes by the space of Disse, which drains lymph into the portal tract lymphatics. [citation needed]
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. [ 6 ] [ 7 ] Hepatocyte growth factor is secreted by platelets , [ 8 ] and mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial ...
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Dendritic cells, mononuclear phagocytes, B lymphocytes, some endothelial cells, epithelium of thymus: T lymphocytes able to respond Cytotoxic T lymphocytes (CD8+) Helper T lymphocytes (CD4+) Origin of antigenic proteins cytosolic proteins (mostly synthesized by the cell; may also enter from the extracellular medium via phagosomes)
Undifferentiated hepatocyte-like cells appear in small, individualized, colonies The cells are available as undifferentiated growth-stage cells that can be grown in-house with the possibility of cell manipulation and amplification; or as fully differentiated cells that are ready and easy-to-use cells with high inter-assay reproducibility and ...
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. [5] [6] [7]The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), remove target glycoproteins from circulation. [1] The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes [ 2 ] and several human carcinoma cell lines [ 3 ] It is also weakly expressed ...