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Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. [5] It was first described as peripheral benzodiazepine receptor ( PBR ), a secondary binding site for diazepam , but subsequent research has found the receptor to be expressed throughout the body and brain. [ 6 ]
The translocon (also known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes. [1] In eukaryotes the term translocon most commonly refers to the complex that transports nascent polypeptides with a targeting signal sequence into the interior (cisternal or lumenal) space of the endoplasmic reticulum (ER) from ...
The protein is directed to the inner membrane by a signal peptide transported across the inner membrane via the Sec machinery. Once in the periplasm, the autotransporter domain inserts into the outer membrane. The passenger domain is passed through the center of the autotransporter domain to be presented on the outside of the cell, however the ...
The protein encoded by the BMAL1 gene in mammals binds with a second bHLH-PAS protein via the PAS domain, CLOCK (or its paralog, NPAS2) to form a heterodimer in the nucleus. [16] Via its BHLH domain, this heterodimer binds to E-box response elements [ 16 ] in the promoter regions of Per ( Per1 and Per2 ) and Cry genes ( Cry1 and Cry2 ). [ 16 ]
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. [1] [2] ANT is the most abundant protein in the inner mitochondrial membrane and belongs to the mitochondrial carrier family ...
11740 Ensembl ENSG00000005022 ENSMUSG00000016319 UniProt P05141 Q6NVC0 P51881 RefSeq (mRNA) NM_001152 NM_007451 RefSeq (protein) NP_001143 NP_001143.2 NP_031477 Location (UCSC) Chr X: 119.47 – 119.47 Mb Chr X: 36.06 – 36.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome. This ...
Translocase is a general term for a protein that assists in moving another molecule, usually across a cell membrane. These enzymes catalyze the movement of ions or molecules across membranes or their separation within membranes.
The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. [5] [6] [7] In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. [8]