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The primary endpoint of a clinical trial is the endpoint for which the trial is powered. Secondary endpoints are additional endpoints, preferably also pre-specified, for which the trial may not be powered.
An outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is used to assess the effect, both positive and negative, of an intervention or treatment. [1] [2] Measures can often be quantified using effect sizes. [3]
A surrogate endpoint of a clinical trial is a laboratory measurement or a physical sign used as a substitute for a clinically meaningful endpoint that measures directly how a patient feels, functions or survives. Changes induced by a therapy on a surrogate endpoint are expected to reflect changes in a clinically meaningful endpoint. [8]
Endpoint (chemistry), the conclusion of a chemical reaction, particularly for titration Outcome measure , a measure used as an endpoint in research Clinical endpoint , in clinical research, a disease, symptom, or sign that constitutes one of the target outcomes of the trial or its participants
Major adverse cardiovascular events (MACE, or major adverse cardiac events) is a composite endpoint frequently used in cardiovascular research. [1] [2] Despite widespread use of the term in clinical trials, the definitions of MACE can differ, which makes comparison of similar studies difficult. [3]
In telecommunications networks, a node (Latin: nodus, ‘knot’) is either a redistribution point or a communication endpoint. A physical network node is an electronic device that is attached to a network, and is capable of creating, receiving, or transmitting information over a communication channel. [1]
After detox, the defendants would be brought back to his courtroom to discuss further treatment options. But when it was suggested that detoxing without medication can lead to overdoses, Bartlett came up short. “I’ll take your word on that,” the judge replied. “I’m not an expert on what works and what doesn’t work.”
The union of two intervals is an interval if and only if they have a non-empty intersection or an open end-point of one interval is a closed end-point of the other, for example (,) [,] = (,]. If R {\displaystyle \mathbb {R} } is viewed as a metric space , its open balls are the open bounded intervals ( c + r , c − r ) , and its closed balls ...