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Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [ 4 ] [ 5 ] [ 2 ] Symptoms in mild cases include high blood pressure and a fast heart rate ; usually without a fever . [ 2 ]
Several years later, physicians concluded the combination of phenelzine and the pethidine given to her by Stone and Weinstein contributed to the development of serotonin syndrome, which led to increased agitation. This led Zion to pull on her intravenous catheter, causing Weinstein to order physical restraints, which Zion also fought against ...
[2] [26] There may be a link between lower 5-hydroxytryptamine (5-HT, i.e. serotonin) receptor availability and symptoms of antidepressant discontinuation syndrome. [ 24 ] [ 27 ] Among antidepressants analyzed by Gastaldon et al. (2022), lofepramine , vortioxetine , mianserin , agomelatine , and esketamine are not associated with significantly ...
The signs and symptoms of Serotonin Syndrome include: Agitation or restlessness. Insomnia. Dilated pupils. Loss of muscle coordination or twitching muscles. Muscle rigidity. Tremor. Heavy sweating.
Serotonin syndrome. Irritability. Flu-like symptoms. Dizziness. Electric shock sensations ... But working with your prescriber is the best way to avoid discontinuation symptoms, serotonin syndrome ...
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [6] [40] The differential diagnosis includes serotonin syndrome, [41] encephalitis, toxic encephalopathy, status epilepticus, heat stroke, catatonia and malignant hyperthermia.
Serotonin syndrome, in which an excess of serotonin in the synapses causes a similar crisis of hypertension and mental confusion, could be confused with an adrenergic storm. Serotonin, being a tryptamine (non-catecholamine) involved in higher brain functions, can cause dangerous hypertension and tachycardia from its effects on the sympathetic ...
The intensity of the symptoms of serotonin syndrome vary over a wide spectrum, and the milder forms are seen even at nontoxic levels. [158] It is estimated that 14% of patients experiencing serotonin syndrome overdose on SSRIs; meanwhile the fatality rate is between 2% and 12%. [153] [159] [160]