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The sweat test measures the concentration of chloride that is excreted in sweat. It is used to screen for cystic fibrosis (CF). [ 1 ] Due to defective chloride channels ( CFTR ), the concentration of chloride in sweat is elevated in individuals with CF.
Sweat diagnostics is an emerging non-invasive technique used to provide insights to the health of the human body. Common sweat diagnostic tests include testing for cystic fibrosis [1] and illicit drugs. [2] Most testing of human sweat is in reference to the eccrine sweat gland which in contrast to the apocrine sweat gland, has a lower ...
However, a small portion of patients with cystic fibrosis, especially those with "mild" mutations of the cystic fibrosis transmembrane regulator (CFTR) ion channel, have near-normal sweat tests. In these cases, a useful diagnostic adjunct involves measuring the nasal transepithelial potential difference (i.e. the charge on the respiratory ...
However, sweat as a diagnostic fluid presents numerous challenges as well, such as very small sample volumes and filtration (dilution) of larger-sized hydrophilic analytes. Currently the only major commercial application for sweat diagnostics is for infant cystic fibrosis testing based on sweat chloride concentrations. [citation needed]
Sweat is necessary to help keep us cool in the heat of the day, but that doesn't mean it doesn't stink.
The normal blood reference range of chloride for adults in most labs is 96 to 106 milliequivalents (mEq) per liter. The normal range may vary slightly from lab to lab. Normal ranges are usually shown next to results in the lab report. A diagnostic test may use a chloridometer to determine the serum chloride level.
Branded content. Us Weekly has affiliate partnerships so we may receive compensation for some links to products and services. Reviewed by Dr. Diana Rangaves, PharmD Struggling to find the right ...
Because the current applied is high compared to the physiological current, the test could be compared to a “stress test” for sweat glands. In fact, firm application of the hands and feet against the electrodes blocks physiological sweating, and the active measure extracts electro-active ions ( i. e. , chloride near the anode, proton near ...