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Experts used to recommend a roughly weeklong “loading phase” in which you consume 20 to 25 grams of creatine daily to “saturate” your muscles before dropping to a lower dose.
Studies that focused on low doses of creatine (3g) taken over a long period of time (think two years) showed little effect on bone density or muscle gain in older women.
Creatine supplements are marketed in ethyl ester, gluconate, monohydrate, and nitrate forms. [40] Creatine supplementation for sporting performance enhancement is considered safe for short-term use but there is a lack of safety data for long term use, or for use in children and adolescents. [41] Some athletes choose to cycle on and off creatine ...
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
Creatine conversion to phosphocreatine is catalysed by creatine kinase; spontaneous formation of creatinine occurs during the reaction. [7] Creatinine is removed from the blood chiefly by the kidneys, primarily by glomerular filtration, but also by proximal tubular secretion. Little or no tubular reabsorption of creatinine occurs. If filtration ...
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In order to minimize injury and maximize results, a novice should begin at a comfortable level of muscular intensity and advance towards overload of the muscles over the course of an exercise program. [8] [9] Progressive overload requires a gradual increase in volume, intensity, frequency or time in order to achieve the targeted goal of the user.
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