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Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. [3] Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon ...
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. [1] It is a long-term condition that results in inflammation and ulcers of the colon and rectum. [1] [7] The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood (hematochezia). [1]
[3] [6] Medication utilized in treatment includes anti-inflammatory agents and corticosteroids to alleviate inflammation and immunomodulators which act to suppress the immune system. Immunomodulators are used in severe cases of ulcerative colitis and often utilized to treat patients with pancolitis who have shown little improvement with anti ...
Collagenous colitis is an inflammatory condition of the colon.Together with the related condition lymphocytic colitis, it is a subtype of microscopic colitis, which is characterized by inflammation that specifically affects the colon (i.e. colitis), and a clinical presentation that involves watery diarrhea but a lack of rectal bleeding.
Axial involvement may occur years before bowel disease. Inflammatory low back pain, buttocks pain, and chest pain are the main complaints. Typically occurring before the age of 45, inflammatory back pain often begins slowly, is often unilateral, sporadic, and worsens while at rest.
Irritable bowel syndrome is a chronic condition that affects the gastrointestinal tract. There is no cure for IBS but many proven treatments. IBS is more common than many realize.
SUDD clinically presents with left lower abdominal pain and bowel habit changes (predominantly diarrhea). The pain is chronic and does not improve with bowel movement, which distinguishes SUDD from irritable bowel syndrome. There is no systemic inflammation in SUDD, evident by lack of fever, normal white blood count and inflammatory markers.
An emerging model of inflammatory bowel disease (IBD) pathogenesis postulates three prerequisite factors: 1) degradation of intestinal barrier function, 2) translocation of luminal contents into the lamina propria and subsequent exposure to immune cells, and 3) an inappropriate immune response. Although intestinal barrier dysfunction is clearly ...