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Urea in low doses is a humectant while at high doses (above 20%) it causes breakdown of protein in the skin. [ 9 ] Urea dissolves the intercellular matrix of the cells of the stratum corneum , promoting desquamation of scaly skin , eventually resulting in softening of hyperkeratotic areas. [ 5 ]
Trichophyton rubrum is a dermatophytic fungus in the phylum Ascomycota.It is an exclusively clonal, [2] anthropophilic saprotroph that colonizes the upper layers of dead skin, and is the most common cause of athlete's foot, fungal infection of nail, jock itch, and ringworm worldwide. [3]
Athlete's foot, known medically as tinea pedis, is a common skin infection of the feet caused by a fungus. [2] Signs and symptoms often include itching, scaling, cracking and redness. [3] In rare cases the skin may blister. [6] Athlete's foot fungus may infect any part of the foot, but most often grows between the toes. [3]
Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons , waxes , or polyethylene glycols as the vehicle for external skin application. [ 1 ]
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
A 2003 survey of diseases of the foot in 16 European countries found onychomycosis to be the most frequent fungal foot infection and estimated its prevalence at 27%. [43] [44] Prevalence was observed to increase with age. In Canada, the prevalence was estimated to be 6.48%. [45]
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